Study of psychotropic effects of Semax on different models of stress

УДК: 616.45-001.1/.3:616.89-008.447
A.L. Yasenyavskaya, V.H. Murtalieva

The experimental work on rats is devoted to the study of the psychotropic effects of Semax (Met-Glu-His-PhePro-Gly-Pro) under conditions of different stressful effects (“information”, “social”, “immune” types of stress). “Information” stress was modeled by the formation of foraging behavior in a multi-alternative labyrinth. A model of sensory contact (inter-males confrontations) was chosen as a model of “social” stress. “Immune” stress was modeled by a single intraperitoneal injection of lipopolysaccharide extracted from Salmonella typhi cells. The psychoemotional state of the animals was assessed by the results of studying the behavior in the “Open Field” and “Porsolt” tests. The results obtained during the study of the psychoemotional state of the animals exposed to the “information”, “social” and “immune” types of stress indicate the formation of an anxiety-depressive state in rats. The results obtained during the experimental study of the psychotropic activity of Semax indicate the ability of the neuropeptide under stressful conditions to produce a psychomodulatory effect, eliminating depressive-like disturbances in animal behavior. Thus, the obtained data confirm the central idea of the concept of stress about its nonspecificity, which implies that any stimulation, regardless of the nature, causes the same reaction in the body, and Semapex - a representative of the neuropeptide group – is regarded as an effective drug with a broad-spectrum antistress activity

Ключевые слова: Semax, neuropeptides, “information” stress, “immune” stress, “social” stress, test “Open field”, test “Porsolt”

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